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In rodents, the upper sensitivity can also be associated to a shorter plasma half-life of T 4 than in humans as a result of appreciable variations between species in the transport proteins for thyroid hormones. In plasma, the T four half-life is about 12—24 h in rats vs 5—9 days in humans, and the serum levels of TSH are about 25 times greater in rodents than in people.
Different studies performed with rats and mice gave no increase within the micronucleus formation in bone marrow cells. Bone marrow smears were ready at 30 h, and polychromatic erythrocytes per animal were scored Gocke et al. An interim sacrifice at 15 months gave no difference in haematology, clinical chemistry, or different clinical pathology parameters and no increased incidence of neoplasms or non-neoplastic lesions. Also, at final sacrifice, there was no evidence of carcinogenic exercise in males or females of each species.

Animals have been maintained for several months with periodic sacrifices Flickinger, The animals have been then examined weekly for 10 further weeks. Sacrificed animals confirmed brown-dyed stomach walls and filling of stomach and small gut with a dark-brown to orange substance. These findings weren't famous in survivors.

Two lengthy-term research with Swiss mice or NZW rabbits, where the animals had been handled with zero. In an in vitro. In an investigation in three human volunteers utilizing situations much like those used in hair dyeing, 14 C-ring-labelled 1. This means that solely a small amount of resorcinol penetrates the skin in the course of the actual means of hair colouring.

• Two long-time period studies with Swiss mice or NZW rabbits, where the animals were handled with zero.





• No thyroid hormone measurements have been performed.





• The F 0 and F 1 females continued to obtain the resorcinol throughout mating, gestation, and lactation and thru the day of euthanasia for research design, see Appendix 7.

Koppers Company studied potential pores and skin irritating results of flaked or industrial resorcinol in male albino rabbits mg beneath occlusive conditions over 24 h, scoring after 24 and seventy two h. In one research performed with male Syrian golden hamsters, which targeted solely on effects on the forestomach, pyloric region, and urinary bladder, the animals were dosed with zero or 0.

Fifty per cent of survivors were sacrificed 1 week later, and blood and urine samples had been taken. Resorcinol showed a concentration-dependent improve in labelling index [ 3 H]thymidine , acanthosis, and papillomatosis. After utility of an ointment containing To examine the goitrogenic exercise of resorcinol, feminine Wistar rats were handled twice daily for 28 days by rubbing 6 g of an ointment containing Increased thyroid gland weights 2.

The bulk of the urine-recovered dye will need to have been taken up into the sexy layer of the skin after which slowly launched into the circulation. A cumulative 4-day absorption assuming cm 2 of scalp was given as zero.

The tolerable intake of zero. It is therefore potential that these neurological results are due to the acute effect of the gavage administration. CNS results in people and animals have been associated with acute publicity to resorcinol.